a)SHOW A FEELING OR ATTITUDEto become very angry and upset 气疯
She completely lost it with one of the kids in class.
她被班上的一个孩子气疯了。
b)CRAZY (also lose the plot) to become crazy or confused 发疯;迷惑
I could see people thinking I’d totally lost the plot.
我看得出来,人们都以为我彻底发疯了。
Examples from the Corpus
lose it• After her mom and dad were killed in the car accident, Ginny just seemed to lose it.• Whytry and pressurize myself into losing it?• Whatever Brad said must have made her angry because she totally lost it.• In fact we had never lost it.• Poorguy, he lost it.• They will not know why you have lost it.• Love, love that had always held pain through fear of losing it but had finally become a torment.• Pete just lost it completely and started shouting and screaming at us.• If they lose it, they will probably lose their majority.• Maybe he had lost it when running away from the fracas of metal and hollowclacking of gunfire.• You really lose it when you get around your family.