loci• The next step is to combine these factors across all loci.• The opera is first and foremost an evocation of geniusloci, and subsequently a gallery of types and humours.• Combining the effects of many loci is nontrivial.• Human ALDHs are encoded at four independant loci on four different chromosomes.• His sense of history and of genius loci was potent.• Genomicclones of both the Oct-11a and Oct-11bloci were isolated from a BALB/clibrary in the vectorl Charon 4A.• The Oct-11a and Oct-11b loci were mapped by interspecific backcross analysis.