refractory• The tale of Gormenghast requires a large number of refractory animals, few of them capable of taking direction.• Initialtherapy of patients with large tumor masses has been complicated by large releases of intracellular potassium with resultantrefractory hyperkalemia.• Monamine oxidase inhibitors are used occasionally in migraine patients who are refractory to other prophylactic drugs.
Originrefractory
(1600-1700)Latinrefractarius, from refragari“to oppose”